Hypocretin-1 (orexin A) prevents the effects of hypoxia/hypercapnia and enhances the GABAergic pathway from the lateral paragigantocellular nucleus to cardiac vagal neurons in the nucleus ambiguus

▶Hypocretin-1 enhances the GABAergic pathway from the LPGi to cardiac vagal neurons. ▶Hypocretin-1 prevents the effects of hypoxia/hypercapnia. ▶Hypocretin-1 evokes long-term facilitation of evoked GABAergic neurotransmission.