کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
6276800 | 1295744 | 2010 | 7 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Associations between the tumor necrosis factor alpha gene (-308GâA) and event-related potential indices of attention and mental rotation
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کلمات کلیدی
RTSERP - برنامه ریزی منابع سازمانAttention - توجهtumor necrosis factor alpha - تومور نکروز عامل آلفاResponse times - زمان پاسخCytokines - سیتوکین هاTumor necrosis factor alpha (TNF-α) - عامل ناباروری تومور آلفا (TNF-α)TNF-α - فاکتور نکروز توموری آلفاEvent-related potentials (ERPs) - پتانسیل مربوط به رویداد (ERPs)Event-related potential - پتانسیل وابسته به رویدادSingle nucleotide polymorphism - پلیمورفیسم تک نوکلئوتیدیMental rotation - چرخش روحیSNP - چندریختی تک-نوکلئوتیدImaging genetics - ژنتیک تصویربرداری
موضوعات مرتبط
علوم زیستی و بیوفناوری
علم عصب شناسی
علوم اعصاب (عمومی)
پیش نمایش صفحه اول مقاله

چکیده انگلیسی
The tumor necrosis factor alpha (TNF-α) is a cytokine that exerts neuroprotective and neurodegenerative effects. While some research suggests enhancing effects of the TNF-α gene (TNF-α -308GâA) on cognitive function, further research is needed to clarify the association between the TNF-α gene and specific areas of cognitive performance including their neurophysiological correlates. In this study we examine association of the TNF-α -308GâA single nucleotide polymorphism (rs1800629) with attention and mental rotation performance in an event-related potential (ERP) study in healthy participants (n=67). The results show that carriers of the -308 A allele display elevated attentional processes (i.e. a stronger N1) as compared to the GG genotype group. Mental rotation performance varied across genotypes when demands on mental rotation were high. Here, carriers of the -308 A allele performed better than the GG genotype group. This is paralleled by the neurophysiological data showing genotype-dependent variations in parietal positivities only under the condition of high demands on mental rotation. The finding of enhanced attentional and mental rotation performance in A allele carriers supports recent findings that the A allele of this single nucleotide polymorphism (SNP) enhances cognitive performance on a general measure of cognitive processing speed.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Neuroscience - Volume 170, Issue 3, 27 October 2010, Pages 742-748
Journal: Neuroscience - Volume 170, Issue 3, 27 October 2010, Pages 742-748
نویسندگان
C. Beste, M. Heil, K. Domschke, B.T. Baune, C. Konrad,