کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
6277176 | 1295749 | 2010 | 14 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Distinct types of non-cholinergic pedunculopontine neurons are differentially modulated during global brain states
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کلمات کلیدی
PBSPedunculopontineSCPRASSNRECoGSubstantia nigra pars reticulataSWAREMsuperior cerebellar peduncle - اسب سواری مخچه بزرگelectrocorticogram - الکتروکورتیکوگرافیrapid eye movement - حرکت سریع چشمreticular activating system - سیستم فعال مجزاLocal network - شبکه محلیCoefficient of Variation - ضریب تغییرbasal ganglia - عقدههای قاعدهایPhosphate buffered saline - فسفات بافر شورslow-wave activity - فعالیت آهستهPPN - مالیات بر ارزش افزودهneocortex - نوقشر، نئوکورتکسPedunculopontine nucleus - هسته PedunculopontineChAT - چتcholine acetyltransferase - کولین استیل ترانسفرازCholinergic - کولینرژیک
موضوعات مرتبط
علوم زیستی و بیوفناوری
علم عصب شناسی
علوم اعصاب (عمومی)
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Distinct types of non-cholinergic pedunculopontine neurons are differentially modulated during global brain states Distinct types of non-cholinergic pedunculopontine neurons are differentially modulated during global brain states](/preview/png/6277176.png)
چکیده انگلیسی
The pedunculopontine nucleus (PPN) is critically involved in brain-state transitions that promote neocortical activation. In addition, the PPN is involved in the control of several behavioral processes including locomotion, motivation and reward, but the neuronal substrates that underlie such an array of functions remain elusive. Here we analyzed the physiological properties of non-cholinergic PPN neurons in vivo across distinct brain states, and correlated these with their morphological properties after juxtacellular labeling. We show that non-cholinergic neurons in the PPN whose firing is not strongly correlated to neocortical activity are highly heterogeneous and are composed of at least three different subtypes: (1) “quiescent” neurons, which are nearly silent during slow-wave activity (SWA) but respond robustly to neocortical activation; (2) “tonic firing” neurons, which have a stationary firing rate that is independent of neocortical activity across different brain states; and (3) “irregular firing” neurons, which exhibit a variable level of correlation with neocortical activity. The majority of non-cholinergic neurons have an ascending axonal trajectory, with the exception of some irregular firing neurons that have descending axons. Furthermore, we observed asymmetric synaptic contacts within the PPN arising from the axon collaterals of labeled neurons, suggesting that excitatory, non-cholinergic neurons can shape the activity of neighboring cells. Our results provide the first evidence of distinct firing properties associated with non-cholinergic neuronal subtypes in the PPN, suggesting a functional heterogeneity, and support the notion of a local network assembled by projection neurons, the properties of which are likely to determine the output of the PPN in diverse behavioral contexts.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Neuroscience - Volume 170, Issue 1, 29 September 2010, Pages 78-91
Journal: Neuroscience - Volume 170, Issue 1, 29 September 2010, Pages 78-91
نویسندگان
H. Roš, P.J. Magill, J. Moss, J.P. Bolam, J. Mena-Segovia,