کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
6277371 | 1295754 | 2010 | 18 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Heterogeneous dopamine populations project to specific subregions of the primate amygdala
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کلمات کلیدی
PFCamygdalostriatal areaABmcAbpCtriton-XIpaCCalbindin-D28kAAAglobus pallidus, external segmentCaBPBNSTAStrPAGCOADATCOPCEMPACNGSBMCAHAGPESCPBpc - BPCSNpr - SNPRaqueduct - آب جوشextended amygdala - آمیگدال گسترش یافتهAChE - آهیsuperior cerebellar peduncle - اسب سواری مخچه بزرگAcetylcholinesterase - استیل کولین استرازDopamine transporter - انتقال دهنده دوپامینphosphate buffer - بافر فسفاتVentricle - بطن چپsubstantia nigra - توده سیاهtyrosine hydroxylase - تیروزین هیدروکسیلازPeriaqueductal grey - خاکستری پرآبیoptic tract - دستگاه نوریDopamine - دوپامینretrorubral field - زمینه بازتولیدnormal goat serum - سرم طبیعی بزpre-frontal cortex - قشر پیش از جلوییmedial lemniscus - لنیزوس مدیاclaustrum - مانعamygdalohippocampal area - منطقه amygdalohippocampalventral tegmental area - ناحیه تگمنتوم شکمیanterior amygdaloid area - ناحیه قدام ناحیه کمریbed nucleus of the stria terminalis - هسته تخت ترمینال های استریlateral nucleus - هسته جانبیinterstitial nucleus of the posterior limb of the anterior commissure - هسته داخلی بین اندام خلفی کمری قدامcaudate nucleus - هسته دم دارred nucleus - هسته قرمزposterior cortical nucleus - هسته قشر خلفیanterior cortical nucleus - هسته قشر قدامیmedial nucleus - هسته محوریHippocampus - هیپوکامپ Putamen - پوسته، پوتامنanterior commissure - کمربند قدامیexternal capsule - کپسول خارجیinternal capsule - کپسول داخلی
موضوعات مرتبط
علوم زیستی و بیوفناوری
علم عصب شناسی
علوم اعصاب (عمومی)
پیش نمایش صفحه اول مقاله

چکیده انگلیسی
Amygdala dysfunction has been reported among patients with various psychiatric disorders, and dopamine is critical to the amygdala's ability to mediate fear conditioning. Recent work indicates that the midbrain dopaminergic neurons have heterogeneous receptor and membrane channel profiles, as well as differential physiologic responses to discrete stimuli. To begin understanding how dopamine affects amygdala physiology and pathology in higher primates, we mapped the inputs from the midbrain dopaminergic neurons to various amygdala nuclei in the monkey using retrograde and anterograde tracing techniques, and single and double immunofluorescence histochemistry for tracer and tyrosine hydroxylase, a dopamine marker. Our results show that the primate amygdala as a whole receives broad input, mostly from the dorsal tier of the substantia nigra, pars compacta, and the A8-retrorubral field. Input from the A10-ventral tegmental area, while present, was less prominent. These results differ from data in the rat, where the midline A10-ventral tegmental area is a major source of dopamine to the amygdala “mesolimbic” pathway. Both the “amygdala proper” and the “extended amygdala” receive the majority of their input from the dorsal tier of the substantia nigra and A8-retrorubral field, but the extended amygdala receives additional modest input from the ventral tier. In addition, the “extended amygdala” structures have a denser input than the “amygdala proper,” with the exception of the lateral core of the central nucleus, which receives no input. Our anterograde studies confirm these findings, and revealed fine, diffuse terminal fibers in the amygdala proper, but a denser network of fibers in the extended amygdala outside the lateral core of the central nucleus. These results indicate that the entire extent of the dorsal tier beyond the A10-ventral tegmental area may regulate the amygdala in primates, and subsequently serve as a source of dysfunction in primate psychopathology.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Neuroscience - Volume 165, Issue 4, 17 February 2010, Pages 1501-1518
Journal: Neuroscience - Volume 165, Issue 4, 17 February 2010, Pages 1501-1518
نویسندگان
Y.T. Cho, J.L. Fudge,