کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
6277808 | 1295775 | 2009 | 12 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Levodopa-sensitive, dynamic changes in effective connectivity during simultaneous movements in Parkinson's disease
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کلمات کلیدی
multivariate autoregressive modelingUPDRSPFCMVCROIBOLDACCMARConnectivity - اتصالParkinson's disease - بیماری پارکینسونfMRI - تصویرسازی تشدید مغناطیسی کارکردیCompensation - جبران خسارتmaximum voluntary contraction - حداکثر انقباض داوطلبانهSMA - دبیرستانprefrontal cortex - قشر prefrontalprimary motor cortex - قشر حرکتی اولیهanterior cingulate cortex - قشر سینگولیت قدامی، کورتکس سینگولیت قدامیSEM - مدل معادلات ساختاری / میکروسکوپ الکترونی روبشیStructural equation modeling - مدلسازی معادلات ساختاریUnified Parkinson's Disease Rating Scale - مقیاس درجه بندی بیماری بیماری پارکینسون متحدregion of interest - منطقه مورد نظرSMA, supplementary motor area - ناحیه حرکتى تکمیلىblood oxygen level-dependent - وابسته به سطح اکسیژن خون
موضوعات مرتبط
علوم زیستی و بیوفناوری
علم عصب شناسی
علوم اعصاب (عمومی)
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چکیده انگلیسی
Changes in effective connectivity during the performance of a motor task appear important for the pathogenesis of motor symptoms in Parkinson's disease (PD). One type of task that is typically difficult for individuals with PD is simultaneous or bimanual movement, and here we investigate the changes in effective connectivity as a potential mechanism. Eight PD subjects off and on l-DOPA medication and 10 age-matched healthy control subjects performed both simultaneous and unimanual motor tasks in an fMRI scanner. Changes in effective connectivity between regions of interest (ROIs) during simultaneous and unimanual task performance were determined with structural equation modeling (SEM), and changes in the temporal dynamics of task performance were determined with multivariate autoregressive modeling (MAR). PD subjects demonstrated alterations in both effective connectivity and temporal dynamics compared with control subjects during the performance of a simultaneous task. l-DOPA treatment was able to partially normalize effective connectivity and temporal patterns of activity in PD, although some connections remained altered in PD even after medication. Our results suggest that difficulty performing simultaneous movements in PD is at least in part mediated by a disruption of effective communication between widespread cortical and subcortical areas, and l-DOPA assists in normalizing this disruption. These results suggest that even when the site of neurodegeneration is relatively localized, study of how disruption in a single region affects connectivity throughout the brain can lead to important advances in the understanding of the functional deficits caused by neurodegenerative disease.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Neuroscience - Volume 158, Issue 2, 23 January 2009, Pages 693-704
Journal: Neuroscience - Volume 158, Issue 2, 23 January 2009, Pages 693-704
نویسندگان
S.J. Palmer, L. Eigenraam, T. Hoque, R.G. McCaig, A. Troiano, M.J. McKeown,