کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
6277871 | 1295775 | 2009 | 7 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Purinergic receptor immunoreactivity in the rostral ventromedial medulla
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کلمات کلیدی
NDSRVMTphTSBTRISImmunohistochemistry - ایمونوهیستوشیمیphosphate buffer - بافر فسفاتTris(hydroxymethyl)aminomethane - تریس (هیدروکسی متیل) آمینومتانrostral ventromedial medulla - روستال ونتومدیال مدولاnormal donkey serum - سرم عسل طبیعیnociception - غربالگریtryptophan hydroxylase - هیدروکسیلاز تریپتوفانPurinergic receptors - گیرنده های Purinergic
موضوعات مرتبط
علوم زیستی و بیوفناوری
علم عصب شناسی
علوم اعصاب (عمومی)
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چکیده انگلیسی
The current study investigates the distribution of P2X, P2Y and P1 receptor immunoreactivity in RVM neurons of Sprague-Dawley rats. Co-localization with tryptophan hydroxylase (TPH), a well-established marker for serotonergic neurons was also studied. Immunoreactivity for the four purinergic receptor subtypes examined was abundant in all anatomical subdivisions of the RVM. By contrast, TPH-immunoreactivity was restricted to a relatively small subset of RVM neurons concentrated in the nucleus raphe magnus and pallidus, as expected. There was a significant degree of co-localization of each purinergic receptor subtype with TPH-immunoreactivity. This co-localization was most pronounced for P2Y1 receptor immunoreactivity, although this was the least abundant among the different purinergic receptor subtypes examined. Immunoreactivity for multiple purinergic receptor subtypes was often co-localized in single neurons. These results confirm the physiological finding that purinergic receptors are widely expressed in the RVM. Purinergic neurotransmission in this region may play an important role in nociception and/or nociceptive modulation, as at other levels of the neuraxis.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Neuroscience - Volume 158, Issue 2, 23 January 2009, Pages 915-921
Journal: Neuroscience - Volume 158, Issue 2, 23 January 2009, Pages 915-921
نویسندگان
L.N. Close, J.S. Cetas, M.M. Heinricher, N.R. Selden,