کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
6278332 | 1295814 | 2007 | 13 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Activation of central 5HT2A receptors reduces the craniofacial nociception of rats
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کلمات کلیدی
PBSTMD(±)-2,5-dimethoxy-4-iodoamphetamineWDR5HT2A receptorTMJ5HTDOIGADNGSventrolateral - ventrolateraltemporomandibular joint disorder - اختلال مفصلی temporomandibularOrofacial pain - درد ناحیه تناسلیreceptive field - زمینه پذیرشTrigeminal subnucleus caudalis - ساب گلبول قرمز Trigeminal caudalisnormal goat serum - سرم طبیعی بزwide dynamic range - طیف گسترده ای پویاmasseter muscle - عضله مسطحnociceptive specific - غیرقابل تشخیص خاص-like immunoreactive - مانند ایمنی فعالPhosphate-buffered saline - محلول نمک فسفات با خاصیت بافریtemporomandibular joint - مفصل گیجگاهی
موضوعات مرتبط
علوم زیستی و بیوفناوری
علم عصب شناسی
علوم اعصاب (عمومی)
پیش نمایش صفحه اول مقاله

چکیده انگلیسی
We assessed the contribution of central 5HT2A receptors to the craniofacial tissue nociception in naïve male rats. First, we tested whether activation of central 5HT2A receptors affected nociceptive neural activities recorded from superficial laminae of the trigeminal subnucleus caudalis (Vc)/upper cervical spinal cord junction (Vc/C2) region. Two types of units, such as deep-nociceptive or skin-wide dynamic range (WDR) units were identified from extracellular recordings. Topical administration of 5HT2A receptor agonist, (±)-2,5-dimethoxy-4-iodoamphetamine (DOI) onto the Vc/C2 region significantly reduced deep-nociceptive unit discharges evoked by formalin injection into the masseter muscle. Noxious pinch stimulation to the facial skin-evoked skin-WDR unit discharges was significantly reduced by topical administration of 0.1 mg/rat DOI onto the Vc/C2 region. Second, we tested whether i.c.v. administration of DOI affected Fos-like immunoreactivity (-LI) evoked by formalin injection into the masseter muscle. Fos-LI was significantly induced mainly at the ventrolateral (vl) area of trigeminal subnucleus interpolaris (Vi)/Vc junction (vl-Vi/Vc) region and Vc/C2 region in vehicle-treated rats. Formalin-evoked Fos-LI was significantly reduced in laminae I-II of the Vc/C2, but not vl-Vi/Vc region after i.c.v. administration of DOI. Finally, orofacial nocifensive behavioral activities evoked by formalin injection into the masseter muscle were significantly reduced by intracisternal administration of DOI. These results suggest that 5HT2A receptors in the Vc/C2 region mediate antinociceptive effects in the craniofacial nociception.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Neuroscience - Volume 147, Issue 4, 29 July 2007, Pages 1090-1102
Journal: Neuroscience - Volume 147, Issue 4, 29 July 2007, Pages 1090-1102
نویسندگان
K. Okamoto, H. Imbe, A. Kimura, T. Donishi, Y. Tamai, E. Senba,