کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
6278393 | 1295816 | 2009 | 19 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Distribution of calcium channel CaV1.3 immunoreactivity in the rat spinal cord and brain stem
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کلمات کلیدی
APCIBA1TBS-T12nNeuNPersistent inward currentPICNGSGFAPPAPPBS10N - 10 نانBSA - BSAadenomatous polyposis coli - آدنوماتوز پولیپوزیس کولی یا آدنوماتوس پولیپوزیس کولای bovine serum albumin - آلبومین سرم گاوImmunoreactivity - ایمنی فعالImmunohistochemistry - ایمونوهیستوشیمیnormal goat serum - سرم طبیعی بزlocus coeruleus - لوکوس سیرولئوسPhosphate-buffered saline - محلول نمک فسفات با خاصیت بافریionized calcium-binding adaptor molecule 1 - ملکول آداپتور اتصال دهنده کلسیم یونیزه 1hypoglossal nucleus - هسته hypoglossalmotor trigeminal nucleus - هسته سه هسته ای موتورdorsal motor nucleus of vagus - هسته موتور پشتی وحشیneuronal nuclei - هسته های نورونیfacial nucleus - هسته چهرهperoxidase anti-peroxidase - پراکسیداز آنتی پراکسیدازGlial fibrillary acidic protein - پروتئین اسیدی فیبریلاسیون گلایالPlateau potential - پلاتفرم پلاتL-type calcium channel - کانال کلسیم L نوع
موضوعات مرتبط
علوم زیستی و بیوفناوری
علم عصب شناسی
علوم اعصاب (عمومی)
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Distribution of calcium channel CaV1.3 immunoreactivity in the rat spinal cord and brain stem Distribution of calcium channel CaV1.3 immunoreactivity in the rat spinal cord and brain stem](/preview/png/6278393.png)
چکیده انگلیسی
The function of local networks in the CNS depends upon both the connectivity between neurons and their intrinsic properties. An intrinsic property of spinal motoneurons is the presence of persistent inward currents (PICs), which are mediated by non-inactivating calcium (mainly CaV1.3) and/or sodium channels and serve to amplify neuronal input signals. It is of fundamental importance for the prediction of network function to determine the distribution of neurons possessing the ion channels that produce PICs. Although the distribution pattern of CaV1.3 immunoreactivity (CaV1.3-IR) has been studied in some specific central nervous regions in some species, so far no systematic investigations have been performed in both the rat spinal cord and brain stem. In the present study this issue was investigated by immunohistochemistry. The results indicated that the CaV1.3-IR neurons were widely distributed across different parts of the spinal cord and the brain stem although with variable labeling intensities. In the spinal gray matter large neurons in the ventral horn (presumably motoneurons) tended to display higher levels of immunoreactivity than smaller neurons in the dorsal horn. In the white matter, a subset of glial cells labeled by an oligodendrocyte marker was also CaV1.3-positive. In the brain stem, neurons in the motor nuclei appeared to have higher levels of immunoreactivity than those in the sensory nuclei. Moreover, a number of nuclei containing monoaminergic cells, for example the locus coeruleus, were also strongly immunoreactive. CaV1.3-IR was consistently detected in the neuronal perikarya regardless of the neuronal type. However, in the large neurons in the spinal ventral horn and the cranial motor nuclei the CaV1.3-IR was clearly detectable in first and second order dendrites. These results indicate that in the rat spinal cord and brain stem CaV1.3 is probably a common calcium channel used by many kinds of neurons to facilitate the neuronal information processing via certain intracellular mechanisms, for instance, PICs.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Neuroscience - Volume 159, Issue 1, 3 March 2009, Pages 217-235
Journal: Neuroscience - Volume 159, Issue 1, 3 March 2009, Pages 217-235
نویسندگان
N. Sukiasyan, H. Hultborn, M. Zhang,