کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
6278663 | 1295836 | 2007 | 9 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Hippocampal neurogenesis is reduced by sleep fragmentation in the adult rat
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کلمات کلیدی
TSDadrenalectomizedSGZ5-bromo-2-deoxyuridineREMADXNREMGCLSFCTBSobstructive sleep apnea - آپنه خواب انسدادیElectroencephalogram - الکتروانسفالوگرافیEMG - الکترومیوگرافیelectromyogram - الکترومیوگرافیphosphate buffer - بافر فسفاتOsa - بخشBrdU - بروموداکسی اوریدینTris-buffered saline - تریس بافر شورrapid eye movement - حرکت سریع چشمnon-rapid eye movement - حرکت سریع چشم نیستdentate gyrus - شکنج دندانه دارcoefficient of error - ضریب خطاsleep fragmentation - قطعه قطعه شدن خوابgranule cell layer - لایه سلول گرانولTotal sleep deprivation - محرومیت از خواب کاملEEG - نوار مغزیNeurogenesis - نوروژنزHippocampus - هیپوکامپ CORT - کورتCorticosterone - کورتیکوسترون
موضوعات مرتبط
علوم زیستی و بیوفناوری
علم عصب شناسی
علوم اعصاب (عمومی)
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Hippocampal neurogenesis is reduced by sleep fragmentation in the adult rat Hippocampal neurogenesis is reduced by sleep fragmentation in the adult rat](/preview/png/6278663.png)
چکیده انگلیسی
SF rats exhibited an increased number of non-rapid eye movement (NREM) sleep bouts with no change in the percent of time spent in this stage. The numbers of both BrdU-positive cells and Ki67-positive cells were reduced by â¼70% (P<0.05) in the SF groups after 4 and 7 days of experimental conditions whereas no differences were observed after 1 day. In a second experiment, we found that the percentage of new cells expressing a neuronal phenotype 3 weeks after BrdU administration was lower in the SF in comparison with the SFC group for all three durations of SF. We also examined the effects of SF on proliferation in adrenalectomized (ADX) animals, with basal corticosterone replacement. ADX SF animals exhibited a 55% reduction in the number of BrdU-positive cells when compared with ADX SFC. Thus, elevated glucocorticoids do not account for most of the reduction in cell proliferation induced by the SF procedure, although a small contribution of stress is not excluded. The results show that sustained SF induced marked reduction in hippocampal neurogenesis.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Neuroscience - Volume 148, Issue 1, 10 August 2007, Pages 325-333
Journal: Neuroscience - Volume 148, Issue 1, 10 August 2007, Pages 325-333
نویسندگان
R. Guzman-Marin, T. Bashir, N. Suntsova, R. Szymusiak, D. McGinty,