کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
6278742 | 1295856 | 2006 | 9 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Perinatal protein malnutrition enhances rewarding cocaine properties in adult rats
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کلمات کلیدی
PBSCPPBSA - BSAbovine serum albumin - آلبومین سرم گاوanalysis of variance - تحلیل واریانسANOVA - تحلیل واریانس Analysis of varianceconditioned place preference - ترجیح محل موظف استSensitization - حساسیتDopamine - دوپامینAversion - غرق شدنPhosphate-buffered saline - محلول نمک فسفات با خاصیت بافریcontrol rats - موش های کنترلPerinatal undernutrition - نارسایی پرویناتالconditioned place preference paradigm - پارادایم ترجیحی مکان شرطanteroposterior - پیشاپیش
موضوعات مرتبط
علوم زیستی و بیوفناوری
علم عصب شناسی
علوم اعصاب (عمومی)
پیش نمایش صفحه اول مقاله

چکیده انگلیسی
The rewarding properties of cocaine were assessed in adult rats submitted to a protein malnutrition schedule from the 14th day of gestation up to 40 days of age (deprived rats), as compared with well-nourished animals (control rats) using the conditioned place preference paradigm. Dose-response curves to cocaine (3, 5, 10, 15, 30, 45 or 60mg/kg i.p.) revealed in deprived rats a conditioning effect with doses of 5 and 10mg/kg; doses of 15 and 30mg/kg did not show any conditioning place preference and doses of 45 and 60mg/kg revealed a significant aversive effect. In control rats, cocaine elicited place preference with doses of 10, 15 and 30mg/kg, whereas 45 and 60mg/kg did not show either conditioning or aversive effects. Furthermore, sensitization to the conditioning effect of cocaine was obtained in deprived animals with a low dosage of cocaine, that was ineffective in controls (5mg/kg/day for 10 days). Related to the higher rewarding effects, sensitized deprived rats showed a selective and significant increase in FosB expression in nucleus accumbens (core and shell) and basolateral amygdala, brain areas related to the rewarding neuronal circuits. These results suggest that a deficient nutritional status during early life may induce in adult subjects an increased responsiveness to behavioral effects of cocaine and/or enhanced its reinforcement properties.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Neuroscience - Volume 137, Issue 1, 2006, Pages 221-229
Journal: Neuroscience - Volume 137, Issue 1, 2006, Pages 221-229
نویسندگان
A. Valdomero, D.F. Bussolino, O.A. Orsingher, G.R. Cuadra,