کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
6278852 | 1615065 | 2016 | 7 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Effects of repeated high-dose methamphetamine and ceftriaxone post-treatments on tissue content of dopamine and serotonin as well as glutamate and glutamine
ترجمه فارسی عنوان
اثرات دوزهای متادم با دوزهای بالا متافاماتامین و سفتریاکسون پس از درمان بر میزان بافت دوپامین و سروتونین و همچنین گلوتامات و گلوتامین
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کلمات کلیدی
متامفتامین، دوپامین، سروتونین، گلوتامات گلوتامین، سفتریاکسون،
موضوعات مرتبط
علوم زیستی و بیوفناوری
علم عصب شناسی
علوم اعصاب (عمومی)
چکیده انگلیسی
Repeated exposure to high doses of methamphetamine (METH) is known to alter several neurotransmitters in certain brain regions. Little is known about the effects of ceftriaxone (CEF), a β-lactam antibiotic, known to upregulate glutamate transporter subtype 1, post-treatment on METH-induced depletion of dopamine and serotonin (5-HT) tissue content in brain reward regions. Moreover, the effects of METH and CEF post-treatment on glutamate and glutamine tissue content are not well understood. In this study, Wistar rats were used to investigate the effects of METH and CEF post-treatment on tissue content of dopamine/5-HT and glutamate/glutamine in the nucleus accumbens (NAc) and prefrontal cortex (PFC). Rats received either saline or METH (10 mg/kg, i.p. every 2 h Ã 4) followed by either saline or CEF (200 mg/kg, i.p, every day Ã 3) post-treatment. METH induced a significant depletion of dopamine and 5-HT in the NAc and PFC. Importantly, dopamine tissue content was completely restored in the NAc following CEF post-treatment. Additionally, METH caused a significant decrease in glutamate and glutamine tissue content in PFC, and this effect was attenuated by CEF post-treatment. These findings demonstrate for the first time the attenuating effects of CEF post-treatment on METH induced alterations in the tissue contents of dopamine, glutamate, and glutamine.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Neuroscience Letters - Volume 634, 10 November 2016, Pages 25-31
Journal: Neuroscience Letters - Volume 634, 10 November 2016, Pages 25-31
نویسندگان
Yusuf S. Althobaiti, Atiah H. Almalki, Sujan C. Das, Fahad S. Alshehri, Youssef Sari,