کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
6278944 | 1296532 | 2016 | 6 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Activation of 5-HT2A/2C receptors reduces the excitability of cultured cortical neurons
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کلمات کلیدی
TTX5-HT2A/2C receptorsgamma-aminobutyricmEPSCsmIPSCs2,5-dimethoxy-4-iodoamphetamine5-HTHyperpolarization-activated cyclic nucleotide-gated5-hydroxytryptamineDOIEGTAHCNHEPESGTPguanosine-5′-triphosphate - guanosine-5'-triphosphateATP - آدنوزین تری فسفات یا ATPsynaptic transmission - انتقال سیناپسیexcitability - تحریک پذیریminiature inhibitory postsynaptic currents - جریان ممانعت کننده پسینپتیکminiature excitatory postsynaptic currents - جریانهای پسینپتیک هیجان انگیز مینیاتوریDIV - دیوdays in vitro - روز in vitroPatch-clamp - پچ گیرGABA - گابا
موضوعات مرتبط
علوم زیستی و بیوفناوری
علم عصب شناسی
علوم اعصاب (عمومی)
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چکیده انگلیسی
The abundant forebrain serotonergic projections are believed to modulate the activities of cortical neurons. 5-HT2 receptor among multiple subtypes of serotonin receptors contributes to the modulation of excitability, synaptic transmissions and plasticity. In the present study, whole-cell patch-clamp recording was adopted to examine whether activation of 5-HT2A/2C receptors would have any impact on the excitability of cultured cortical neurons. We found that 2,5-Dimethoxy-4-iodoamphetamine (DOI), a selective 5-HT2A/2C receptor agonist, rapidly and reversibly depressed spontaneous action potentials mimicking the effect of serotonin. The decreased excitability was also observed for current-evoked firing. Additionally DOI increased neuronal input resistance. Hyperpolarization-activated cyclic nucleotide-gated cationic channels (HCN) did not account for the inhibition of spontaneous firing. The synaptic contribution was ruled out in that DOI augmented excitation and attenuated inhibition to actually favor an increase in the excitability. Our findings revealed that activation of 5-HT2A/2C receptors reduces neuronal excitability, which would deepen our understanding of serotonergic modulation of cortical activities.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Neuroscience Letters - Volume 632, 6 October 2016, Pages 124-129
Journal: Neuroscience Letters - Volume 632, 6 October 2016, Pages 124-129
نویسندگان
Lingli Hu, Chunhua Liu, Minyan Dang, Bin Luo, Yiping Guo, Haitao Wang,