کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
6278964 | 1296532 | 2016 | 23 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Heterozygous Che-1 KO mice show deficiencies in object recognition memory persistence
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
علم عصب شناسی
علوم اعصاب (عمومی)
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چکیده انگلیسی
Transcriptional regulation is a key process in the formation of long-term memories. Che-1 is a protein involved in the regulation of gene transcription that has recently been proved to bind the transcription factor NF-κB, which is known to be involved in many memory-related molecular events. This evidence prompted us to investigate the putative role of Che-1 in memory processes. For this study we newly generated a line of Che-1+/â heterozygous mice. Che-1 homozygous KO mouse is lethal during development, but Che-1+/â heterozygous mouse is normal in its general anatomical and physiological characteristics. We analyzed the behavioral characteristic and memory performance of Che-1+/â mice in two NF-κB dependent types of memory. We found that Che-1+/â mice show similar locomotor activity and thigmotactic behavior than wild type (WT) mice in an open field. In a similar way, no differences were found in anxiety-like behavior between Che-1+/â and WT mice in an elevated plus maze as well as in fear response in a contextual fear conditioning (CFC) and object exploration in a novel object recognition (NOR) task. No differences were found between WT and Che-1+/â mice performance in CFC training and when tested at 24 h or 7 days after training. Similar performance was found between groups in NOR task, both in training and 24 h testing performance. However, we found that object recognition memory persistence at 7 days was impaired in Che-1+/â heterozygous mice. This is the first evidence showing that Che-1 is involved in memory processes.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Neuroscience Letters - Volume 632, 6 October 2016, Pages 169-174
Journal: Neuroscience Letters - Volume 632, 6 October 2016, Pages 169-174
نویسندگان
Gisela Zalcman, Nicoletta Corbi, Maria Grazia Di Certo, Elisabetta Mattei, Noel Federman, Arturo Romano,