کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
6279019 1615066 2016 9 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
The cortical surface correlates of clinical manifestations in the mid-stage sporadic Parkinson's disease
ترجمه فارسی عنوان
سطوح قشر مرتبط با تظاهرات بالینی در بیماری پارکینسون اختلال درسطح مرحله است
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی علوم اعصاب (عمومی)
چکیده انگلیسی
The alteration of pathological cortical surface may lead to the corresponding clinical manifestations of sporadic Parkinson's disease (sPD). Therefore, we investigated the correlates of cortical surface and clinical manifestations in the mid-stage sPD. Sixty seven mid-stage sPD patients and thirty five matched controls were performed the corticometry of magnetic resonance imaging (MRI) and the assessment of clinical manifestations including the demographic and disease-related characteristics, and underwent the final analysis of the correlates between cortical surface and clinical manifestations. The result revealed a significant correlation between CDT and Frontal-Sup-Orb-L, Frontal-Sup-Medial-L, Frontal-Mid-Orb-L and Rectus-L; SVFT and Frontal-Mid-L and Frontal-Inf-Tri-L; DF and Frontal-Sup-R, Frontal-Mid-R and Frontal-Sup-Medial-R; Webster and Occipital-Mid-R, Angular-R, Temporal-Sup-R and Temporal-Mid-R respectively in the mid-stage sPD patients. Our data suggested that the alterations of cortical surface in the left Frontal-Sup-Orb, Sup-Medial, Mid-Orb, Mid, Inf-Tri and Rectus, the right Frontal-Sup, Mid, Sup-Medial, and Occipital-Mid, Angular, Temporal-Sup and Temporal-Mid were the pathological base of some clinical manifestations including the cognitive impairment, the space structure, memory, attention, the abstract thinking, design, layout, utilization, digital, calculation, the time and spatial orientation concept, the operation sequence recognition and the partial motor dysfunctions in the mid-stage sPD, and that the dysfunctions of these brain regions contributed by the cortical surface lesion were closely correlated with some clinical manifestations of mid-stage sPD.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Neuroscience Letters - Volume 633, 28 October 2016, Pages 125-133
نویسندگان
, , , , , , , , , ,