Research articleResting state theta band source distribution and functional connectivity in remitted schizophrenia

- Increased resting theta activity is one of the most consistent observations occurring during all the phases of schizophrenia illness.
- Resting state theta oscillations during the remission phase are yet unclear.
- Low-resolution brain electromagnetic tomography (LORETA) is an electrophysiological approach, which address the restricted spatial resolution of EEG.
- Statistically significant and increased theta band current source density was found in the dominant anterior cingulate cortex.
- Connectivity analysis showed increased theta band connectivity between the inferior parietal lobe bilaterally and between the left inferior parietal lobe and right middle frontal gyrus.

Increased resting theta activity is one consistent observation occurring during all the phases of schizophrenia. However, the resting theta oscillations during the remission phase are yet unclear. We studied resting theta current source density and functional connectivity in remitted schizophrenia and compared with healthy controls. Significantly increased current source density was found in the dominant anterior cingulate cortex. Increased connectivity between the inferior parietal lobe bilaterally and between the left inferior parietal lobe and right middle frontal gyrus was also found. It may be concluded that schizophrenia patients have aberrant regional theta band current source density and functional connectivity even during remission.