کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
6279876 1615084 2016 5 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Research paperPlatelet-activating factor attenuation of long-term potentiation in rat hippocampal slices via protein tyrosine kinase signaling
ترجمه فارسی عنوان
ضعیف شدن عامل رشد پلاکتی در طولانی مدت در برش های هیپوکامپ موش از طریق سیگنالینگ پروتئین تیروزین کیناز
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی علوم اعصاب (عمومی)
چکیده انگلیسی


- PAF attenuated LTP in rat hippocampal slices.
- PAF attenuation of LTP was mediated via PAF receptors.
- Tyrosine kinase signaling was involved in PAF-mediated reduction of LTP.

It is well established that HIV-1-infected mononuclear phagocytes release platelet activating factor (PAF) and elevated levels of PAF have been detected in blood and in the cerebrospinal fluid (CSF) of acquired immunodeficiency syndrome (AIDS) patients with HIV-associated neurocognitive disorders (HAND). It is our hypothesis that the elevated levels of PAF alter long-term potentiation (LTP) in the hippocampus, leading to neurocognitive dysfunction. To test this hypothesis, we studied the effects of PAF on LTP in the CA1 region of rat hippocampal slices. Our results showed incubation of hippocampal slices with PAF attenuated LTP. The PAF-mediated attenuation was blocked by ginkgolide B, a PAF receptor antagonist, suggesting PAF attenuation of LTP via PAF receptors. Application of lyso-PAF, an inactive PAF analog, had no apparent effect on LTP. Further investigation revealed an involvement of tyrosine kinase in PAF attenuation of LTP, which was demonstrated by lavendustin A (a specific protein tyrosine kinase inhibitor) blockage of PAF attenuation of LTP. As LTP is widely considered as the cellular and synaptic basis for learning and memory, the attenuation of LTP by PAF may contribute at least in part to the HAND pathogenesis.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Neuroscience Letters - Volume 615, 26 February 2016, Pages 83-87
نویسندگان
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