کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
6279955 1615082 2016 5 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
The impact of childhood maltreatment on redox state: Relationship with oxidative damage and antioxidant defenses in adolescents with no psychiatric disorder
ترجمه فارسی عنوان
تأثیر سوء رفتارهای دوران کودکی در حالت ردوکس: ارتباط با آسیب اکسیداتیو و دفاع آنتی اکسیدانی در نوجوانان بدون اختلال روانپزشکی
کلمات کلیدی
استرس اکسیداتیو، استرس زودرس، بدرفتاری دوران کودکی، بیومارکرهای آنتی اکسیدان،
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی علوم اعصاب (عمومی)
چکیده انگلیسی
Early life stress (ELS) has been associated with biological and psychosocial alterations due to developmental reprogramming. Here, we investigated whether childhood maltreatment is associated with an imbalance between the production of oxidative markers and antioxidant defenses. Thirty adolescents with no psychiatric disorder but reporting childhood maltreatment and twenty-seven adolescents with no psychiatric disorder and no history of ELS were recruited for the study. Childhood maltreatment was investigated by the Childhood Trauma Questionnaire (CTQ). Redox state was estimated by plasma levels of protein carbonylation, total thiol content (SH), superoxide dismutase (SOD), glutathione peroxidase (GPx), as well as total reactive antioxidant potential (TRAP). Childhood maltreatment was associated with oxidative stress as shown by increased protein carbonylation. Interestingly, adolescents exposed to maltreatment also displayed higher SOD levels, TRAP kinetics and reduced GPx levels when compared with adolescents who had not undergone childhood maltreatment. No significant differences were observed for SH levels. Taken together, we provide novel evidence indicating that childhood maltreatment is associated with increased oxidative stress markers in otherwise healthy adolescents.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Neuroscience Letters - Volume 617, 23 March 2016, Pages 173-177
نویسندگان
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