کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
6280037 1615087 2016 6 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
A microPET comparison of the effects of etifoxine and diazepam on [11C]flumazenil uptake in rat brains
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی علوم اعصاب (عمومی)
پیش نمایش صفحه اول مقاله
A microPET comparison of the effects of etifoxine and diazepam on [11C]flumazenil uptake in rat brains
چکیده انگلیسی
Using positron emission tomography (PET), the present study assessed the binding of [11C]flumazenil to GABA-A receptors in anesthetized rats following a single intravenous injection of an active dose of either etifoxine (25 mg/kg) or diazepam (1 mg/kg), which are both anxiolytic drugs. [11C]flumazenil binding was measured in five discrete brain structures, namely the caudate putamen, hippocampus, cerebellum, occipital cortex and parietal cortex. As expected, diazepam injection produced a significant decrease in [11C]flumazenil binding, which was interpreted as benzodiazepine GABA-A receptor occupancy, whereas etifoxine increased the binding of [11C]flumazenil. This first use of in vivo imaging after etifoxine administration revealed the activated binding pattern of [11C]flumazenil and highlighted the pharmacological differences between etifoxine and benzodiazepines. Using the same [11C]flumazenil radiotracer, PET neuroimaging could be applied to larger animals and, ultimately, to human subjects, thus providing new perspectives for better defining the molecular pharmacology of etifoxine.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Neuroscience Letters - Volume 612, 26 January 2016, Pages 74-79
نویسندگان
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