کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
6280075 1615087 2016 6 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Research paperIncreased alcohol consumption in relaxin-3 deficient male mice
ترجمه فارسی عنوان
افزایش مصرف الکل در موشهای نابالغ آرامشبن 3
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی علوم اعصاب (عمومی)
چکیده انگلیسی


- Relaxin-3 KO male mice show enhanced alcohol intake and preference.
- Wild-type and KO mice show similar increased alcohol intake after chronic alcohol inhalation.
- No genotype difference was detected in sucrose or quinine preference.

Relaxin-3 is a neuropeptide expressed in the brainstem, and predominantly localized in the gray matter of the midline dorsal pons termed the nucleus incertus. Relaxin-3-expressing neurons densely project axons rostrally to various forebrain regions including the septum, hippocampus, and lateral hypothalamus. Several relaxin-3 functions have been reported including food intake, stress responses, neuroendocrine function, emotion, and spatial memory. In addition, recently relaxin-3 and its receptor, RXFP3, were shown to regulate alcohol intake using an RXFP3 antagonist and RXFP3 gene knockout mice. In the present study, we investigated alcohol consumption in relaxin-3 knockout mice, and found that male but not female mice significantly drank more alcohol than wild-type mice in the two-bottle choice test. However, after chronic alcohol vapor exposure, wild-type and mutant mice did not show this difference in alcohol intake, although both genotypes exhibited increased alcohol consumption compared with non-alcohol-exposed control mice. There was no genotype difference in sucrose or quinine preference. These results suggest that the relaxin-3 neuronal system modestly affects alcohol preference and consumption.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Neuroscience Letters - Volume 612, 26 January 2016, Pages 155-160
نویسندگان
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