Cerebral alterations of type 2 diabetes mellitus on MRI: A pilot study

This study is to investigate gray matter volume, cortical thickness, and surface area of the brain in patients with type 2 diabetes mellitus (T2DM). High resolution T1-weighted MR images were obtained from eighteen T2DM and seventeen normal controls. All images were processed using our newly developed BrainLab toolbox. Declines of gray matter volume, cortical thickness, and surface area were found in T2DM patients. Significantly reduced ROIs of gray matter volume happened in subcortical gray nuclei (left caudate and right caudate), and significantly reduced ROIs of cortical thickness occurred in temporal lobe (left superior temporal gyrus), parietal lobe (left angular gyrus), and occipital lobe (right superior occipital gyrus, left middle occipital gyrus and right cuneus). Apparently reduced ROIs of surface area were mainly distributed in frontal lobe (right superior frontal gyrus (dorsal) and left paracentral lobule). The findings indicated that T2DM caused brain changes in specific regions. This work revealed neural alterations of T2DM, which had a great significance in early diagnosis of the disease.