کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
6280587 | 1615092 | 2015 | 23 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Gabapentin attenuates neuropathic pain and improves nerve myelination after chronic sciatic constriction in rats
ترجمه فارسی عنوان
گاباپنتین درد نوروپاتیک را کاهش می دهد و میلیناس عصب را پس از سفتی مزمن اسکیزوفرنی در موش صحرایی بهبود می بخشد
دانلود مقاله + سفارش ترجمه
دانلود مقاله ISI انگلیسی
رایگان برای ایرانیان
کلمات کلیدی
گاباپنتین، عصب سیاتیک، درد عصبی، میلینین عصبی،
موضوعات مرتبط
علوم زیستی و بیوفناوری
علم عصب شناسی
علوم اعصاب (عمومی)
چکیده انگلیسی
Gabapentin (GBP) is an anti-convulsive drug often used as analgesic to control neuropathic pain. This study aimed at evaluating oral GBP treatment (30, 60, 120Â mg/kg, 60Â min prior to chronic constriction of the sciatic nerve (CCSN) along 15-day treatment post-injury, 12Â h/12Â h) by monitoring spontaneous and induced-pain behaviors in Wistar rats on 5th and 15th days post-injury during early neuropathic events. CCSN animals receiving saline were used as controls. Another aim of this study was to evaluate GBP effects on myelin basic protein (MBP) on the 5th and 15th days post-injury and nerve morphology by transmission electron microscopy to address nerve regeneration. On the 5th and 15th days, GBP (60Â mg/kg) reduced neuropathic pain behaviors (scratching and biting) in the ipsilateral paw and alleviated mechanical allodynia in comparison with the neuropathic saline group. GBP significantly increased climbing and rearing behaviors in CCSN and CCSN-free animals suggesting increased motor activity rather than sedation. We found three-fold significant increase in MBP expression by western blots on the 15th day when compared to controls. In addition, GPB (60Â mg/kg) improved nerve axonal, fiber and myelin area 15 days post-surgery. In conclusion, GBP alleviated mechanical and thermal allodynia and spontaneous pain-related behaviors and improved later nerve morphology. Our findings suggest that GBP improve nerve remyelination after chronic constriction of the sciatic nerve.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Neuroscience Letters - Volume 607, 21 October 2015, Pages 52-58
Journal: Neuroscience Letters - Volume 607, 21 October 2015, Pages 52-58
نویسندگان
Carlos C. Câmara, Celina V. Araújo, Kalina Kelma Oliveira de Sousa, Gerly A.C. Brito, Mariana L. Vale, Ramon da Silva Raposo, Fabiana Evaristo Mendonça, Bruno S. Mietto, Ana Maria B. Martinez, Reinaldo B. Oriá,