کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
6280859 1615108 2015 6 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Research articleNeuroprotective effects of crocin against traumatic brain injury in mice: Involvement of notch signaling pathway
ترجمه فارسی عنوان
مقاله پژوهشی اثرات نوروپروتیک کروسین در برابر آسیب مغزی آسیب دیده در موش صحرایی: دخالت مسیر سیگنال
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی علوم اعصاب (عمومی)
چکیده انگلیسی


- Pretreatment of crocin (20 mg/kg) conferred neuroprotective effects on the mice against TBI.
- Pretreatment of crocin (20 mg/kg) significantly increased the Notch signaling activation after TBI.
- Inhibition of Notch signaling attenuated the ability of crocin to protect mice against TBI.

This study investigated the protective effects and mechanisms of crocin, an extract of saffron, on brain damage after traumatic brain injury (TBI) in mice. C57BL/6 mice were subjected to controlled cortical impact (CCI)-induced TBI. Pretreatment with crocin (20 mg/kg) had protective effects against TBI, demonstrated by improved neurological severity score (NSS) and brain edema, decreased microglial activation and release of several pro-inflammatory cytokines, and decreased cell apoptosis. TBI activated Notch signaling, as shown by upregulated levels of Notch intracellular domain (NICD) and Hes1 mRNA, and pretreatment with crocin further increased Notch activation. However, pretreatment with DAPT (100 mg/kg), a gamma-secretase inhibitor, significantly suppressed crocin-induced activation of Notch signaling and attenuated the ability of crocin to protect mice against TBI-induced inflammation and apoptosis. Therefore, these results suggest that crocin has neuroprotective effects against TBI in mice, and these effects are at least partially dependent on activation of Notch signaling.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Neuroscience Letters - Volume 591, 30 March 2015, Pages 53-58
نویسندگان
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