کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
6280962 | 1615104 | 2015 | 7 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
β-Adrenergic receptor agonist increases voltage-gated Na+ currents in medial prefrontal cortex pyramidal neurons
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
علم عصب شناسی
علوم اعصاب (عمومی)
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: β-Adrenergic receptor agonist increases voltage-gated Na+ currents in medial prefrontal cortex pyramidal neurons β-Adrenergic receptor agonist increases voltage-gated Na+ currents in medial prefrontal cortex pyramidal neurons](/preview/png/6280962.png)
چکیده انگلیسی
The prefrontal cortex does not function properly in neuropsychiatric diseases and during chronic stress. The aim of this study was to test the effects of isoproterenol, a β-adrenergic receptor agonist, on the voltage-dependent fast-inactivating Na+ currents in medial prefrontal cortex (mPFC) pyramidal neurons obtained from young rats. The recordings were performed in the cell-attached configuration. Isoproterenol (2 μM) did not change the peak Na+ current amplitude but shifted the IV curve of the Na+ currents toward hyperpolarization. Pretreatment of the cells with the β-adrenergic antagonists propranolol and metoprolol abolished the effect of isoproterenol on the Na+ currents, suggesting the involvement of β1-adrenergic receptors. The effect of β-adrenergic receptor stimulation on the sodium currents was dependent on kinase A and kinase C; the effect was diminished in the presence of the kinase A antagonist H-89 and the kinase C antagonist chelerythrine and abolished when the antagonists were coapplied. Moreover, isoproterenol depolarized the membrane potential recorded using the perforated-patch method, and this depolarization was abolished by cesium ions. Thus, in mPFC pyramidal neurons, stimulation of β-adrenergic receptors up-regulates the fast-inactivating voltage-gated Na+ currents evoked by suprathreshold depolarizations.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Neuroscience Letters - Volume 595, 19 May 2015, Pages 87-93
Journal: Neuroscience Letters - Volume 595, 19 May 2015, Pages 87-93
نویسندگان
Bartlomiej Szulczyk,