کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
6281001 | 1615105 | 2015 | 4 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Variation in complement protein C1q is not a major contributor to cognitive impairment in Parkinson's disease
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موضوعات مرتبط
علوم زیستی و بیوفناوری
علم عصب شناسی
علوم اعصاب (عمومی)
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Variation in complement protein C1q is not a major contributor to cognitive impairment in Parkinson's disease Variation in complement protein C1q is not a major contributor to cognitive impairment in Parkinson's disease](/preview/png/6281001.png)
چکیده انگلیسی
Traditional dogma regarding the brain as an immune exempt organ has changed in recent years. New research has highlighted the role of the classical complement cascade in both synaptic elimination and function, driven largely by the role of the pathway initiating protein C1q. Given the links between C1q and cognitive function we assessed the genetic variability of the C1q encoding genes: C1QA, C1QB and C1QC between PD patients and matched controls. Despite a strong link between C1Q/cognitive decline and PD/cognitive decline we were unable to find a link between common C1Q variation and PD. We conclude that common C1Q-A/B/C genetic variation is unlikely to contribute to cognitive decline or the missing heritability in PD.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Neuroscience Letters - Volume 594, 6 May 2015, Pages 66-69
Journal: Neuroscience Letters - Volume 594, 6 May 2015, Pages 66-69
نویسندگان
Sophia Carbutt, Jennifer Duff, Alison Yarnall, David J. Burn, Gavin Hudson,