کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
6281047 | 1615110 | 2015 | 6 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
The electroretinogram of Mongolian gerbil (Meriones unguiculatus): Comparison to mouse
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
علم عصب شناسی
علوم اعصاب (عمومی)
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: The electroretinogram of Mongolian gerbil (Meriones unguiculatus): Comparison to mouse The electroretinogram of Mongolian gerbil (Meriones unguiculatus): Comparison to mouse](/preview/png/6281047.png)
چکیده انگلیسی
The Mongolian gerbil (Meriones unguiculatus) is a diurnal rodent whose retinal photoreceptors comprise 13% cones in contrast to 1-3% in nocturnal mice and rats. Moreover, it displays a retinal structure more analogous to that of human than of mouse. However, the electroretinogram (ERG) recordings of gerbils have not yet been well studied. Thus, here we compared the ERGs of gerbils and C57 mice. We recorded responses to full-field flashes of increasing intensities under both dark and light adaptation. We also investigated responses to flickers of increasing frequencies and to long-duration flashes under photopic conditions. In scotopic, the amplitudes of the gerbil a- and b-waves are slightly smaller than those of the mouse waves. However, in photopic, the gerbil wave amplitudes are 2-fold larger than those of mice. Gerbils also exhibit larger flicker responses and higher flicker fusion frequencies than mice. Furthermore, unlike mice, gerbils show a positive OFF response (d-wave) and a post b-wave positive potential (i-wave), features commonly observed in human photopic ERGs. Our results suggest that gerbils may complement rod-dominant mice as models for studying retinal cone function and pathologies.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Neuroscience Letters - Volume 589, 4 March 2015, Pages 7-12
Journal: Neuroscience Letters - Volume 589, 4 March 2015, Pages 7-12
نویسندگان
Shengyan Yang, Xiaopeng Luo, Guoyin Xiong, Kwok-Fai So, Hui Yang, Ying Xu,