کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
6281242 1615112 2015 4 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Association of the mt-ND2 5178A/C polymorphism with Parkinson's disease
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی علوم اعصاب (عمومی)
پیش نمایش صفحه اول مقاله
Association of the mt-ND2 5178A/C polymorphism with Parkinson's disease
چکیده انگلیسی
Mitochondria play an important role in the etiology of Parkinson's disease (PD). While mutations in the mitochondrial DNA (mtDNA) have been shown to accumulate in PD, no specific mtDNA polymorphisms have been associated with susceptibility or resistance to PD. A cytosine to adenine transversion at base pair 5178 in the mtDNA has been associated with increased longevity and resistance against a number of age related disorders and has been shown to decrease mitochondrial reactive oxygen species (ROS) production. We sought to determine whether 5178A is associated with resistance against PD in a Han Chinese population. To assess its association with PD, we genotyped 484 idiopathic PD patients and 710 control individuals for 5178C/A. Genotyping was performed using restriction fragment length polymorphism (RFLP) analysis. There was no significant association between 5178A and PD (P = 0.308) when analyzing the entire population. However, sub-group analysis revealed that in males the frequency of 5178A was significantly lower in PD patients (27.7% in controls vs 20.0% in PD patients, P = 0.027). Stratification of the population by age showed that this trend held across age groups but only reached statistical significance in males aged 60-70 (29.1% in controls vs 14.05 in PD patients, P = 0.011). In conclusion, we demonstrated that the frequency of 5178A was significantly decreased in male PD patients in a Han Chinese population. This polymorphism may be associated with resistance against the development of PD when in combination with loci on the Y chromosome.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Neuroscience Letters - Volume 587, 5 February 2015, Pages 98-101
نویسندگان
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