کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
6281309 | 1615111 | 2015 | 6 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
The change of circulating insulin like growth factor binding protein 7 levels may correlate with postoperative cognitive dysfunction
ترجمه فارسی عنوان
تغییر انسولین گردش خون مانند پروتئین 7 پروتئین اتصال دهنده عامل رشد ممکن است با اختلال شناختی پس از عمل مرتبط باشد
دانلود مقاله + سفارش ترجمه
دانلود مقاله ISI انگلیسی
رایگان برای ایرانیان
کلمات کلیدی
اختلال شناختی پس از عمل، فاکتور رشد مانند انسولین-1، پروتئین اتصال دهنده فاکتور رشد مانند انسولین 7، بیهوشی عمومی،
موضوعات مرتبط
علوم زیستی و بیوفناوری
علم عصب شناسی
علوم اعصاب (عمومی)
چکیده انگلیسی
Insulin-like growth factor binding protein (IGFBP) 7 may be a critical regulator of memory consolidation. This study was performed to assess the relationship between circulating IGFBP7 levels and postoperative cognition dysfunction (POCD) in patients scheduled for elective head and neck carcinoma surgery under general anesthesia. Among one hundred and two patients included in this study, forty-four patients completed collection of all four blood samples and thirty-five patients were diagnosed with POCD. The results of Mini-Mental State Examination (MMSE) test and enzyme-linked immunosorbent assay showed that postoperative MMSE score and circulating insulin-like growth factor (IGF)-1 level were lower and circulating IGFBP7 level was higher than preoperative level. Circulating IGF-1 level was significantly lower and D-value of preoperative and postoperative day 1 circulating IGFBP7 levels (ÎIGFBP71) was significantly higher in the POCD group. Age preoperative MMSE, IGF-1 level and ÎIGFBP71 significantly correlated with POCD, but preoperative IGFBP7 level not. Logistic regression analysis revealed that older patients, lower preoperative MMSE score, IGF-1 level and higher IGFBP7 level significantly increased the risk of POCD, but ÎIGFBP71 not. Hence, circulating IGF-1 and IGFBP7 levels and their changes during operation under general anesthesia may correlate with POCD, but further investigation in larger samples is needed.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Neuroscience Letters - Volume 588, 19 February 2015, Pages 125-130
Journal: Neuroscience Letters - Volume 588, 19 February 2015, Pages 125-130
نویسندگان
Jue Jiang, Zhifeng Chen, Bing Liang, Jia Yan, Ying Zhang, Hui Xu, Yan Huang, Hong Jiang,