کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
6281365 | 1615115 | 2015 | 5 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Phenazine derivatives cause proteotoxicity and stress in C. elegans
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کلمات کلیدی
NACC. elegansPCNUPRphenazine-1-carboxylic acid1-HPPCA - PCAα-synuclein - α-سینوکلینER stress - استرس استHuntington's disease - بیماری هانتینگتونParkinson's disease - بیماری پارکینسونUbiquitin proteasome system - سیستم پروتئازوم UbiquitinN-acetyl cysteine - نیتستیل سیستئینUnfolded protein response - پاسخ پروتئین آشکارPolyglutamine - پلیگلوتامینPhenazines - پنتازینPyocyanin - پیوسیانینUPS - یو پی اس
موضوعات مرتبط
علوم زیستی و بیوفناوری
علم عصب شناسی
علوم اعصاب (عمومی)
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
It is widely recognized that bacterial metabolites have toxic effects in animal systems. Phenazines are a common bacterial metabolite within the redox-active exotoxin class. These compounds have been shown to be toxic to the soil invertebrate Caenorhabditis elegans with the capability of causing oxidative stress and lethality. Here we report that chronic, low-level exposure to three separate phenazine molecules (phenazine-1-carboxylic acid, pyocyanin and 1-hydroxyphenazine) upregulated ER stress response and enhanced expression of a superoxide dismutase reporter in vivo. Exposure to these molecules also increased protein misfolding of polyglutamine and α-synuclein in the bodywall muscle cells of C. elegans. Exposure of worms to these phenazines caused additional sensitivity in dopamine neurons expressing wild-type α-synuclein, indicating a possible defect in protein homeostasis. The addition of an anti-oxidant failed to rescue the neurotoxic and protein aggregation phenotypes caused by these compounds. Thus, increased production of superoxide radicals that occurs in whole animals in response to these phenazines appears independent from the toxicity phenotype observed. Collectively, these data provide cause for further consideration of the neurodegenerative impact of phenazines.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Neuroscience Letters - Volume 584, 1 January 2015, Pages 23-27
Journal: Neuroscience Letters - Volume 584, 1 January 2015, Pages 23-27
نویسندگان
Arpita Ray, Courtney Rentas, Guy A. Caldwell, Kim A. Caldwell,