کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
6281855 | 1615129 | 2014 | 6 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Effect of inflammatory challenge on hypothalamic neurons expressing orexinergic and melanin-concentrating hormone
ترجمه فارسی عنوان
تأثیر چالش التهابی بر روی نورونهای هیپوتالاموس که بیان کننده هورمون متابولیسم اواکسینرژیک و ملانین هستند
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
علم عصب شناسی
علوم اعصاب (عمومی)
چکیده انگلیسی
Neurons containing the hypothalamic peptides orexin-A (hypocretin 1) and melanin-concentrating hormone (MCH) have been reported numerous roles in the regulation of the sleep-wake cycle, energy balance and feeding behavior. We investigated the response of these cells to repeated administration of low doses of endotoxin lipopolysaccharide (LPS) in mice. Adult male C57/6J mice where intraperitoneally (i.p.) injected with either LPS or phosphate-buffered saline (PBS) weekly for either 4 or 8 weeks, and afterwards were sacrificed at different time intervals from last injection. A significant drop in orexin-containing neuron number, but not in numbers of MCH or neuronal nuclear antigen (NeuN)-immunoreactive neurons, was observed after 8 weeks of LPS treatment, as compared to PBS treatment. Orexin expression entirely returned to control levels 30 days after the last LPS injection in mice treated for 8 weeks. These data strongly suggest the occurrence of selective alterations of orexinergic system, reversible over time, following repeated and intermittent systemic inflammatory challenge in mice.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Neuroscience Letters - Volume 570, 6 June 2014, Pages 47-52
Journal: Neuroscience Letters - Volume 570, 6 June 2014, Pages 47-52
نویسندگان
Maria Palomba, Paul Faustin Seke Etet, Carlo Veronesi,