کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
6281987 | 1615130 | 2014 | 6 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Combination of transcranial direct current stimulation and methylphenidate in subacute stroke
ترجمه فارسی عنوان
ترکیبی از تحریک جریان مستقیم ترانس کرانانیال و متیل فنیدیت در سکته مغزی ناحیه ای
دانلود مقاله + سفارش ترجمه
دانلود مقاله ISI انگلیسی
رایگان برای ایرانیان
موضوعات مرتبط
علوم زیستی و بیوفناوری
علم عصب شناسی
علوم اعصاب (عمومی)
چکیده انگلیسی
Noninvasive transcranial direct current stimulation (tDCS) and methylphenidate (MP) are associated with motor recovery after stroke. Based on the potentially complementary mechanisms of these interventions, we examined whether there is an interactive effect between MP and tDCS. In this preliminary study, we randomized subacute stroke subjects to receive tDCS alone, MP alone or combination of tDCS and MP. A blinded rater measured safety, hand function, and cortical excitability before and after treatment. None of the treatments caused any major or severe adverse effects or induced significant differences in cortical excitability. Analysis of variance of gain score, as measured by Purdue pegboard test, showed a significant between-group difference (F(2,6) = 12.167, p = 0.008). Post hoc analysis showed that the combination treatment effected greater Purdue pegboard gain scores than tDCS alone (p = 0.017) or MP alone (p = 0.01). Our preliminary data with nine subjects shows an interesting dissociation between motor function improvement and lack of motor corticospinal plasticity changes as indexed by transcranial magnetic stimulation in subacute stroke subjects.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Neuroscience Letters - Volume 569, 21 May 2014, Pages 6-11
Journal: Neuroscience Letters - Volume 569, 21 May 2014, Pages 6-11
نویسندگان
Qing Mei Wang, Huashun Cui, Soo Jeong Han, Randie Black-Schaffer, Magdalena Sarah Volz, Yong-Tae Lee, Seth Herman, Lydia Abul Latif, Ross Zafonte, Felipe Fregni,