کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
6282300 | 1615139 | 2014 | 5 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Long-term potentiation by activation of group I metabotropic glutamate receptors at excitatory synapses in the spinal trigeminal subnucleus oralis
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
علم عصب شناسی
علوم اعصاب (عمومی)
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چکیده انگلیسی
In this study, I examined if activation of group I metabotropic glutamate receptors (mGluRs; mGluR1 and 5) induces long-term potentiation (LTP) at excitatory synapses in the ascending pathway from the spinal trigeminal subnuclei caudalis (Vc) to oralis (Vo), in which group I mGluRs are strongly expressed. As a result, the activation of group I mGluRs produced an initial short-lasting depression and subsequently a delayed type of long-term potentiation (LTP) of excitatory synaptic transmission. Analyses of paired pulse ratio and coefficient of variation indicated that the initial short-lasting depression was induced presynaptically, whereas LTP was expressed postsynaptically. In addition, the short-lasting depression and LTP were mostly mediated by mGluR1, and only partially by mGluR5 and the N-methyl-d-aspartate receptor. Thus, this study suggests that group I mGluRs play an important role in the expression of LTP in the Vc-to-Vo pathway.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Neuroscience Letters - Volume 560, 7 February 2014, Pages 36-40
Journal: Neuroscience Letters - Volume 560, 7 February 2014, Pages 36-40
نویسندگان
Dong-ho Youn,