کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
6282354 | 1615140 | 2014 | 4 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Persistent sodium current properties in hippocampal CA1 pyramidal neurons of young and adult rats
دانلود مقاله + سفارش ترجمه
دانلود مقاله ISI انگلیسی
رایگان برای ایرانیان
موضوعات مرتبط
علوم زیستی و بیوفناوری
علم عصب شناسی
علوم اعصاب (عمومی)
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Persistent sodium current properties in hippocampal CA1 pyramidal neurons of young and adult rats Persistent sodium current properties in hippocampal CA1 pyramidal neurons of young and adult rats](/preview/png/6282354.png)
چکیده انگلیسی
Persistent tetrodotoxin-sensitive sodium current (INaP) plays an important role in cellular and neuronal network excitability in physiological conditions and under different pathological circumstances. However, developmental changes in INaP properties remain largely unclear. In the present study using whole cell patch clamp technique we evaluated INaP properties in CA1 hippocampal pyramidal neurons isolated from young (postnatal day (P) 12-16) and adult (P60-75) rats. We show that the INaP density is substantially larger in the adult group. Although INaP inactivation characteristics were found to be similar in both groups, voltage dependence of INaP activation is shifted to more negative membrane potentials (young: â48.6 ± 0.5 mV vs. adult: â52.4 ± 0.2 mV, p < 0.01). Our data indicates the increase of INaP contribution in the basal membrane sodium conductivity in the mature hippocampus.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Neuroscience Letters - Volume 559, 24 January 2014, Pages 30-33
Journal: Neuroscience Letters - Volume 559, 24 January 2014, Pages 30-33
نویسندگان
Oleksii Lunko, Dmytro Isaev, Oleksandr Maximyuk, Gleb Ivanchick, Vadym Sydorenko, Oleg Krishtal, Elena Isaeva,