کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
6282604 | 1615142 | 2013 | 6 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Acute and subchronic effects of buspirone on attention and impulsivity in the five-choice serial reaction time task in rats
ترجمه فارسی عنوان
اثرات حاد و زیر سیکل بوسیپرون بر توجه و تکانشگری در وظیفه زمان واکنش سریال 5 در موش صحرایی
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موضوعات مرتبط
علوم زیستی و بیوفناوری
علم عصب شناسی
علوم اعصاب (عمومی)
چکیده انگلیسی
Serotonin (5-HT)-related drugs are extensively employed in the treatment of mental disorders. However, the roles of the central serotonergic system in impulse control over environmental stimuli remain to be elucidated. The present study demonstrated acute and subchronic effects of a 5-HT1A receptor partial agonist, buspirone, on the performance of rats in response control indexed by the attentional accuracy and impulsive reactivity in the five-choice serial reaction time task (5-CSRTT). Acute buspirone (0.5Â mg/kg) affected accuracy, whereas subchronic buspirone treatment augmented impulsivity. Moreover, a subchronic buspirone regimen potentiated the acute buspirone-induced reduction in motor impulsivity. Our data suggested that a time-dependent mechanism was involved in the serotonin-associated behavioral control of response accuracy and motoric impulsivity.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Neuroscience Letters - Volume 556, 27 November 2013, Pages 210-215
Journal: Neuroscience Letters - Volume 556, 27 November 2013, Pages 210-215
نویسندگان
Chao-Lin Lu, Yu-Chi Ku, Shih-Mao Lo, Chia-Ho Peng, Che-Se Tung, You-Wei Lin, Yia-Ping Liu,