کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
6282855 1615148 2013 6 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Dimensionality reduced cortical features and their use in predicting longitudinal changes in Alzheimer's disease
ترجمه فارسی عنوان
ابعاد ویژگی های قشر و استفاده از آنها در پیش بینی تغییرات طولی در بیماری آلزایمر را کاهش داد
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی علوم اعصاب (عمومی)
چکیده انگلیسی
Neuroimaging features derived from the cortical surface provide important information in detecting changes related to the progression of Alzheimer's disease (AD). Recent widespread adoption of neuroimaging has allowed researchers to study longitudinal data in AD. We adopted cortical thickness and sulcal depth, parameterized by three-dimensional meshes, from magnetic resonance imaging as the surface features. The cortical feature is high-dimensional, and it is difficult to use directly with a classifier because of the “small sample size” problem. We applied manifold learning to reduce the dimensionality of the feature and then tested the usage of the dimensionality reduced feature with a support vector machine classifier. Principal component analysis (PCA) was chosen as the method of manifold learning. PCA was applied to a region of interest within the cortical surface. We used 30 normal, 30 mild cognitive impairment (MCI) and 12 conversion cases taken from the ADNI database. The classifier was trained using the cortical features extracted from normal and MCI patients. The classifier was tested for the 12 conversion patients only using the imaging data before the actual conversion. The conversion was predicted early with an accuracy of 83%.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Neuroscience Letters - Volume 550, 29 August 2013, Pages 17-22
نویسندگان
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