کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
6282856 1615148 2013 6 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
White-matter density abnormalities in depressive patients with and without childhood neglect: A voxel-based morphometry (VBM) analysis
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی علوم اعصاب (عمومی)
پیش نمایش صفحه اول مقاله
White-matter density abnormalities in depressive patients with and without childhood neglect: A voxel-based morphometry (VBM) analysis
چکیده انگلیسی
Childhood maltreatment (abuse or neglect) can result in changes to the brain structures and functions that underlie adult depression. Few studies have explored the impact of childhood maltreatment on white-matter microstructure, especially for childhood neglect. Nineteen depressive patients who experienced childhood neglect, 21 depressive patients who did not experience childhood neglect, and 20 healthy control subjects were compared in this study. The Childhood Trauma Questionnaire (CTQ), Hamilton Depressive Rating Scale (HAMD), Self-Rating Depression Scale (SDS), and Dysfunctional Attitude Scale (DAS) were used to evaluate each subject. High-resolution T1-weighted 3 T magnetic resonance imaging scans and a whole-brain optimized voxel-based morphometry (VBM) approach were also used. Compared with healthy controls, the depressive group of subjects with childhood neglect showed significantly lower white-matter densities in the bilateral inferior parietal lobe (IPL) [43 −32 24] [−42 −42 25], whereas the depressive group without childhood neglect showed significantly lower densities in bilateral sub-lobar extra-nuclear white matter [27 −15 16] [−27 32 4]. White-matter densities in the bilateral sub-lobar extra-nuclear [−25 −17 18] [27 −13 20] and right brainstem midbrain [9 −34 −13] regions were higher in the depressive patients with childhood neglect than in the depressive patients without childhood neglect. White-matter densities in the bilateral inferior parietal lobe were negatively correlated with neglect total scores on the CTQ and with HAMD and DAS scores. White-matter densities in the bilateral sub-lobar extra-nuclear region were only negatively correlated with HAMD scores. Subjects that have depression with or without childhood neglect show different white-matter microstructural abnormalities.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Neuroscience Letters - Volume 550, 29 August 2013, Pages 23-28
نویسندگان
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