New nicotinic analogue ZY-1 enhances cognitive functions in a transgenic mice model of Alzheimer's disease

► ZY-1 has high affinity to α4β2-nAChR. ► ZY-1 decreased the escape latency in acquisition trials of the Morris water maze test. ► ZY-1 increased the times in the platform quadrant of transgenic mice in Morris water maze test. ► ZY-1 increased platform crossing times in Morris water maze test. ► ZY-1 decreased the escape latency in Morris water maze test.