Honokiol inhibits the inflammatory reaction during cerebral ischemia reperfusion by suppressing NF-κB activation and cytokine production of glial cells

► Honokiol inhibits brain edema and BBB injury. ► Honokiol suppresses NF-κB activation. ► Honokiol reduces NO production in cultured glial cells. ► Honokiol inhibits TNF-α production in cultured glial cells. ► Honokiol decreases RANTES production in cultured glial cells.