Modulation of MAPK and Akt signaling pathways in proximal segment of injured sciatic nerves

► ERK and JNK pathways were inhibited in proximal segments of crushed sciatic nerves. ► Phosphorylated p38 consistently increased from day 1 to day 15 after injury. ► Phosphorylated AKT was augmented in ipsilateral proximal nerves and located in Schwann cells. ► mTOR/p70S6 were activated at early phase after injury. ► The contralateral nerves had some compensable response to the crush injury.