The effect of electroacupuncture on extinction responding of heroin-seeking behavior and FosB expression in the nucleus accumbens core

► Electroacupuncture facilitated the extinction responding of heroin seeking. ► Electroacupuncture did not alter locomotor activity in drug-naïve rats. ► Electroacupuncture attenuated FosB expression in the nucleus accumbens core. ► Acupuncture with extinction therapy may be a novel strategy for drug relapse.