Effects of roscovitine, a cell cycling-dependent kinase inhibitor, on intraocular pressure of rabbit and retinal ganglion cell damage

► R-isomer and S-isomer of roscovitine showed IOP lowering effect in rabbit. ► R-isomer of roscovitine enhanced retinal ganglion cell death. ► S-isomer of roscovitine had a protective effect against retinal ganglion cell death.