Induction of methionine sulfoxide reductase activity by pergolide, pergolide sulfoxide, and S-adenosyl-methionine in neuronal cells

► Methionine sulfoxide reductase (Msr) is upregulated in neurons by small compounds. ► Msr activity is upregulated upon treatment with pergolide and pergolide sulfoxide. ► Msr activity is upregulated upon treatment with S-adenosyl-methionine. ► The compound-mediated upregulated Msr activity may alleviate neuronal malfunction.