Effect of PACAP on MAP kinases, Akt and cytokine expressions in rat retinal hypoperfusion

► Effects of intravitreal PACAP was tested in hypoperfusion-induced retinal injury. ► PACAP attenuates inflammatory cytokine response upon ischemia in the retina. ► PACAP induces ERK1/2 and Akt activation in ischemic retina. ► PACAP inhibits JNK and p38 MAPK expression.