Impaired prefrontal-amygdala effective connectivity is responsible for the dysfunction of emotion process in major depressive disorder: A dynamic causal modeling study on MEG

► We use DCM for MEG to perform effective connectivity analysis in depression. ► Bayesian model selection shows dynamic causal modeling can handle subcortical region. ► Impaired top-down PFC-amygdala connectivity is vital for depressions' dysfunctions.