In vivo comparison of harmine efficacy against psychostimulants: Preferential inhibition of the cocaine response through a glutamatergic mechanism

► Harmine displays selective efficacy against different drugs of abuse in vivo. ► Harmine preferentially antagonizes cocaine-induced stereotyped responses in planarians. ► Harmine efficacy against cocaine is reduced by a glutamate transporter subtype 1 (GLT-1) inhibitor. ► Harmine displays efficacy against methamphetamine. ► Harmine displays efficacy against the psychoactive bath salt compound mephedrone.