siRNA knockdown of ADAM-10, but not ADAM-17, significantly reduces fractalkine shedding following pro-inflammatory cytokine treatment in a human adult brain endothelial cell line

► ADAM-10 siRNA treated cells shed significantly less fractalkine under TNF treatment. ► ADAM-17 siRNA treated cells shed control levels of fractalkine under TNF treatment. ► ADAM-10 is responsible for TNF-induced shedding of fractalkine in hCMEC/D3 cells.