Striatum specific protein, Rhes regulates AKT pathway

► Rhes interacts with p85 regulatory subunit of PI3K, via C-terminal unique tail. ► Interaction between p85 and Rhes is enhanced upon growth factor treatment in vitro. ► AKT translocation to the membrane is facilitated in the presence of Rhes. ► Rhes is a novel striatal regulator of the AKT-mediated pathway in the striatum.