Study of the genetic variability in a Parkinson's Disease gene: EIF4G1

► Mutations in the EIF4G1 gene have been found in patients with Parkinson's Disease (PD) [2]. ► We investigate the mutations in a familial PD cohort and in sub-Saharian Africans and Europeans. ► We failed to identify any mutation in the PD cohort. We identify the p.A502V (previously associated to PD) in Caucasians. ► Mutations in the EIF4G1 gene are a very rare cause of PD in European individuals. ► The protein can tolerate some extent of genetic variability.