Nylon filament coated with paraffin for intraluminal permanent middle cerebral artery occlusion in rats

► In this study we tested the effects of paraffin-coated nylon filament for rat MCAO model. ► Rats models of MCAO with paraffin-coated nylon filament (cMCAO) have larger infarct areas. ► Rats models in cMCAO group have lower mortality. ► The success rate in cMCAO group is 100% (n = 20). ► The paraffin-coated nylon filament was applicable to making MCAO model.