CRMP4 mediates MAG-induced inhibition of axonal outgrowth and protection against Vincristine-induced axonal degeneration

► We examine the role of CRMP4 in MAG-induced axonal responses using CRMP4−/− mice. ► We show involvement of CRMP4 in MAG-induced inhibition of axonal outgrowth. ► MAG-induced axonal protection against acute toxic insult also requires CRMP4. ► CRMP4−/− DRG neurons have elevated sensitivity to Vincristine-induced axonal degeneration.