Dextromethorphan inhibition of voltage-gated proton currents in BV2 microglial cells

► Dextromethorphan inhibits voltage-gated proton currents in BV2 microglial cells. ► Dextromethorphan does not change the reversal potential. ► Dextromethorphan does not change the voltage dependence of the gating. ► Dextrorphan and 3-hydroxymorphinan are ineffective to inhibit proton currents. ► Dextromethorphan methiodide is ineffective to inhibit proton currents.